Reduced Apaf-1 expression in human cutaneous melanomas
نویسندگان
چکیده
منابع مشابه
Apoptosis in cutaneous melanomas.
Cutaneous melanomas has become one of the most discussed and studied tumor because its particular immunologic development but also its increasing rate worldwide in the last decades. Even thought many patients are diagnosed at an early stage, the death rate continues to rise due to the increasing incidence of more advanced lesions. The aim of this study is to detect apoptosis in 30 cases of cuta...
متن کاملA comparison of the expression and properties of Apaf-1 and Apaf-1L.
Apaf-1 is a mammalian homolog of CED-4 that regulates cell death by participating in a ternary complex with cytochrome c, and procaspase-9. In the case of CED-4, two splice variants exist. The smaller (CED-4S) is proapoptotic while the larger (CED-4L) contains a short in-frame insert and is anti-apoptotic. We cloned a murine variant of apaf-1, termed apaf-1L, which contains an eleven amino acid...
متن کاملClinical appearance of cutaneous melanomas.
Brown and black spots are present on the skin of all people. Melanomas compromise only a very small percentage of all such pigmented lesions but are responsible for most of the deaths and illness caused by pigment cells. Three types of melanomas can be distinguished from their clinical, histologic, and biologic characteristics: lentigo maligna, superficial spreading melanoma, and nodular melano...
متن کاملCutaneous melanomas associated with nevi.
OBJECTIVE To determine the frequency of and the histologic and clinical factors associated with melanoma existing in histologic contiguity with a nevus. DESIGN Pathology reports from melanomas collected from January 1, 1993, to December 31, 1997, were retrospectively reviewed. SETTING Independent, community-based dermatopathology laboratory. PATIENTS A total of 1606 patients with a histol...
متن کاملRecent advances in diagnosing cutaneous melanomas
Early detection of lesions while minimising the unnecessary removal of benign lesions is the clinical aim in melanoma diagnosis. In this context, several non-invasive diagnostic modalities, such as dermoscopy, total body photography, and reflectance confocal microscopy have emerged in recent years aiming at increasing diagnostic accuracy. The main developments in this field are the integration ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2004
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6602092